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Isaac Scientific Publishing
Journal of Advances in Molecular Biology
Dr. GUOXUN CHEN,  University of Tennessee, USA
Department of Nutrition
College of Education, Health and Human Sciences
The University of Tennessee
301A Jessie Harris Bldg., 1215 W. Cumberland Ave.
Knoxville, TN 37996
Research Interests
Regulation of hepatic gene expression by nutrients (such as Vitamin A) and hormones (such as insulin) in health and disease models. The long term goal is to understand molecular mechanisms of hepatic insulin resistance associated with obesity and Type 2 diabetes.
Selected Publication List
•Chen G. Assaying of TGFs Produced by MA782/5s-8101 Mouse Mammary Tumor Cell Line. (1988) The Postgraduate Journal of Wuhan University. 1:93-95.
•Chen, G. and Li, W.X., (1989) Studies of Cell Growth Stimulating Factors in Malignant Lung Adenocarcinoma Pleural Effusions. The Cancer Research on Prevention and Treatment, 16:200-202.
•Yuan, X., Chen, G. and. Li, W.X., (1989) In Vitro Antitumor Action of Salvia Chinese Bent to Human Stomach and Oharyngeal Carcinoma Cells. The Cancer Research on Prevention and Treatment, 16:7-9.
•Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O’Doherty, R., Newgard, C.B., and Unger, R.H., (1996) Disappearance of Body Fat in Normal Rats Induced by Adenovirus-Mediated Leptin Gene Therapy. Proceedings of the National Academy of Sciences USA 93:14795-14799.
•Koyama, K., Chen, G., Wang, M.-Y., Lee, Y.H., Shimabukuro, M., Newgard, C.B., and Unger, R.H.. (1997) ß-Cell Function in Normal Rats Made Chronically Hyperleptinemic by Adenovirus-Leptin Gene Therapy. Diabetes 46:1276-1280.
•Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C.B., and Unger, RH. (1997) Direct Antidiabetic Effect of Leptin through Triglyceride Depletion of Tissue. Proceedings of the National Academy of Sciences USA 94:4637-4641.
•Koyama, K., Chen, G., Lee, Y., and Unger, R.H. (1997) Tissue Triglycerides, Insulin Resistance and Insulin Production: Implications for Hyperinsulinemia of Obesity. American Journal of Physiology 273:E708-E713.
•Koyama, K., Shimabukuro, M., Chen, G., Wang, M.-Y., Lee, Y., Kalra, P.S., Dube, M.G., Kalra, S.P., Newgard, C.B., and Unger, R.H. (1998) Resistance to Adenovirally Induced Hyperleptinemia in Rats: Comparison of Ventromedial Hypothalamic Lesions with Mutated Leptin Receptors. The Journal of Clinical Investigation 102:728-733.
•Hohmeier, H., Mulder, H., Chen, G., Henkel-Reiger, R., Prentki, M., and Newgard, C.B. (2000) Isolation of INS-1-Derived Cell Lines With Robust KATP Channel-Dependent and -Independent Glucose-Stimulated Insulin Secretion. Diabetes 49:424-430.
•Chen, G., Hohmeier, H., Gasa, R., Tran, V., and Newgard, C.B. (2000) Selection of Insulinoma Cell Lines With Resistance to IL-1ß and IFN--Induced Cytotoxicity. Diabetes: 49:562-570.
•Chen, G., Hohmeier, H., and Newgard, C.B. (2001) Expression of the Transcription Factor STAT-1 in Insulinoma Cells Protects Against Cytotoxic Effects of Multiple Cytokines. The Journal of Biological Chemistry 276: 766-772.
•Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Kahn, C.R., Granner, D.K., Newgard, C.B., and Spiegelman, B.M.. (2001) Control of Hepatic Gluconeogenesis Through the Transcriptional Coactivator PGC-1. Nature: 413:131-138.
•Tran, V.V., Chen, G., Newgard, C.B., and Hohmeier, H.E. (2003) Discrete and Complementary Mechanisms of Protection of Beta-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy. Diabetes: 52:1423-1432.
•Hohmeier, H.E., Tran, V.V., Chen, G., Gasa, R., and Newgard, C.B. (2003) Inflammatory Mechanisms in Diabetes: Lessons from the Beta-Cell. International Journal of Obesity and Related Metabolic Disorders 27: S12-6 (Suppl 3).
•Newgard, C.B., Hohmeier, H.E., Lu, D., Jensen, M.V., Tran, V.V., Chen, G., Burgess, S., and Sherry, A.D. (2004) Understanding Basic Mechanisms of Beta-Cell Function and Survival: Prelude to New Diabetes Therapies. Cell Biochemistry and Biophysics 40:159-168 (3 Suppl).
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