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MOCR > Volume 3, Number 1, February 2018

One-Pot Synthesis of Novel Derivatives of Dithioxopyrido[2,3-d:6,5-d’]dipyrimidine-4,6-diones Using Hap-Encapsulated γ-Fe2O3Supported Sulfonic Acid Nanocatalyst

Download PDF  (740.8 KB)PP. 1-10,  Pub. Date:February 1, 2018
DOI: 10.22606/mocr.2018.31001

Author(s)
Manouchehr Mamaghani, Laya. Moslemi, Abed Badrian
Affiliation(s)
Department of Chemistry, Faculty of Science, University of Guilan, PO Box 41335-1914, Rasht, Iran.
Department of Chemistry, Faculty of Science, University of Guilan, PO Box 41335-1914, Rasht, Iran.
Department of Basic Science, Research Institution for Educational Studies, OERP, PO Box 15875-4874, Tehran-Iran.
Abstract
A series of novel dithioxopyrido[2,3-d:6,5-d’]dipyrimidine-4,6-dione derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe2O3[γ- Fe2O3@HAP-SO3H] catalyzed condensation of 6-amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one and various substituted aryl aldehydes at 110 oC in DMF. In this protocol the use of nanocatalyst provided a green, useful and rapid method to generate the products in short reaction times and good to excellent yields (70–95%) and the catalyst is easily separated by applying an external magnetic field.

Keywords
Pyrido[2,3-d]pyrimidines, three-component, dipyrimidine, [γ-Fe2O3@HAP-SO3H], nanocatalyst.
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