Isaac Scientific Publishing

Modern Organic Chemistry Research

Fabricating Green Mansion for the Synthesis of (2HB) INH and Its Scaffolds: UV-Visible Determinations for Selective Probe towards Co+2 ions

Download PDF (542.5 KB) PP. 131 - 138 Pub. Date: August 3, 2017

DOI: 10.22606/mocr.2017.23006


  • Devendra S. Raghuvanshi
    School of Chemical Sciences, North Maharashtra University, Jalgaon-425 001 (MS), India
  • Nandkishor B. Shirsath

    School of Chemical Sciences, North Maharashtra University, Jalgaon-425 001 (MS), India
  • Pramod P. Mahulikar*

    School of Chemical Sciences, North Maharashtra University, Jalgaon-425 001 (MS), India
  • Jyotsna S. Meshram

    School of Chemical Sciences, North Maharashtra University, Jalgaon-425 001 (MS), India; Department of Chemistry, RTM Nagpur University, Nagpur-440 033 (MS), India


The present work is emphasizing on the use of solid acid catalysts for the condensation of INH with 2-hydroxy benzaldehyde and its acetyl and benzoyl scaffolds. The Montmorrillonite K 10 clay and Amberlyst are proved highly efficient in catalysing the reactions. Both catalysts offer several advantages like energy efficiency, short reaction time and easy separation techniques over conventional methods and provide safer pathways. The synthesized isonicotinohydrazide (INH) derivative is showing the excellent binding ability with some transition metal ions. The (2HB) isonicotinohydrazide is readily forming complexes with the transition metal ions like Zn+2, Cu+2, Co+2, Ni+2 etc. The (2HB) INH is found to have selective probe towards the Co+2 ions estimated from UV-Visible spectrometric analysis. The synthesis of complex could be easily observed by simple visual determinations.


Green Chemistry, INH, Amberlyst, Montmorrillonite K 10 clay, Chemo selectivity etc


[1] Anastas, Paul T., Warner, John C., “Green chemistry: theory and practice” Oxford, New York: Oxford University Press. ISBN 9780198502340, 1998.

[2] James H. Clark, “Catalysis for green chemistry" Pure Appl. Chem., Vol. 73, pp. 103–111, 2001.

[3] Devendra S. Raghuvanshi, Pramod P. Mahulikar and Jyotsna S. Meshram, "MFA zeotype catalyst: a greener approach for the synthesis of INH azomethine scaffolds." RSC Adv., Vol. 5, pp. 48071–48078, 2015.

[4] Da-Lei Sun, Jian-Ru Deng, and Zi-Sheng Chao, Chemistry Central Journal, 27, 2007.

[5] Kenneth D. M. Harris "New in situ solid-state NMR strategies for exploring materials formation and adsorption processes: prospects in heterogenous catalysis" Appl Petrochem Res, Vol. 6, pp. 295-306, 2016.

[6] Sarvesh Kumar Srivastava, Ryosuke Yamada, Chiaki Ogino, Akihiko Kondo, "Biogenic synthesis and characterization of gold nanoparticles by Escherichia coli K12 and its heterogeneous catalysis in degradation of 4- nitrophenol" Nanoscale Research Letters, Vol. 8, pp. 70- 79, 2013.

[7] Debasish Sengupta and Basudeb Basu, "An efficient heterogeneous catalyst (CuO@ ARF) for on-water CS coupling reaction: an application to the synthesis of phenothiazine structural scaffold." Organic and Medicinal Chemistry Letters, Vol. 4, pp.17, 2014.

[8] Shaobin Wang, “Application of solid ash based catalysts in heterogeneous catalysis” Environ. Sci. Technol, Vol. 42, pp. 7055–7063, 2008.

[9] Junjiang Zhu, Hailong Li, Linyun Zhong, Ping Xiao, Xuelian Xu, Xiangguang Yang, Zhen Zhao, and Jinlin Li "Perovskite oxides: preparation, characterizations, and applications in heterogeneous catalysis." ACS Catal. Vol. 4, pp. 2917?2940, 2014.

[10] Noritaka Mizuno and Makoto Misono, "Heterogeneous catalysis" Chem. Rev. 98, pp. 199?217, 1998.

[11] Jin Y-Q., Ma X-J., Jiang X-G., Liu H-M., Li X-D., Yan J-H., Cen K-F., "Effects of hydrothermal treatment on the major heavy metals in fly ash from municipal solid waste incineration" Energy & Fuels, Vol. 27, pp. 394-399, 2013.

[12] D. S. Raghuvanshi, J. R. Badgujar, P. P. Mahulikar and J. S. Meshram, “Fly Ash Utilization for Sustainable Environment Management: Waste to Resource Material” pp. 190-203, 2014.

[13] I. V. Kuz′min, N. A. Sokolova, I. R. Subbotina, and G. M. Zhidomiro, Russian Chemical Bulletin, International Edition, Vol. 64, No. 2, pp. 278—283, 2015.

[14] N. G. Grigorieva,a M. R. Agliullin,a V. P. Talzi,b O. V. Vodyankina,c and B. I. Кutepova, "Nitration of 1, 3, 3- trimethyl-1-phenylindane on mesoporous aluminosilicates." Russian Chemical Bulletin, International Edition, Vol. 64, pp. 852—858, 2015.

[15] X. Querol, N. Moreno, A. Alastuey, R. Juan, J. M. Andres, A. Lopez-soler, C. Ayora, A. Medinaceli and A. Valero, "Synthesis of high ion exchange zeolites from coal fly ash" Geol. Acta, Vol. 5, pp. 49–57, 2007.

[16] J. Jiang, J. Yu and A. Corma, "Extra‐Large‐Pore Zeolites: Bridging the Gap between Micro and Mesoporous Structures." Angew. Chem., Vol. 49, pp. 3120–3145, 2010.

[17] Gopalpur Nagendrappa, "Organic synthesis using clay and clay-supported catalysts." Applied Clay Science, Vol. 53, pp. 106–138, 2011.

[18] A. Vaccari "Clays and catalysis: a promising future." Applied Clay Science, Vol. 14, pp. 161–198, 1999.

[19] Gopalpur Nagendrappa, "Organic synthesis using clay catalysts" Resonance, pp. 64-77, 2002.

[20] P. P. Kumavat, D. S. Dalal, “Fabrication of Organic Solar Cells based on Photosensitive Small Molecules and Study of Electron Acceptor Layer Effect on Efficiency” Modern Organic Chemistry Research, Vol. 1, pp. 35-42, 2016.

[21] Navjeet Kaur and Dharma Kishore, "Montmorillonite: An efficient, heterogeneous and green catalyst for organic synthesis" Journal of Chemical and Pharmaceutical Research, Vol. 4, pp. 991-1015, 2012.

[22] Pal Rammohan, Taradas Sarkar, and Shampa Khasnobis. "Amberlyst-15 in organic synthesis." Arkivoc, pp. 570- 609, 2012.

[23] Gerhard Wenz, Clinical Drug Investigation, Vol. 19, pp. 21–25, 2000.

[24] Jump up Schwarz, F. J. Kirchgessner M., Stangl G. I., "Cobalt requirement of beef cattle – feed intake and growth at different levels of cobalt supply" Journal of Animal Physiology and Animal Nutrition, Vol. 83, pp. 121–131, 2000.

[25] K. Li, J. Valla and J. G. Martinez, "Realizing the commercial potential of hierarchical zeolites: new opportunities in catalytic cracking." ChemCatChem, Vol. 6, pp. 46–66, 2014.

[26] M. Malhotra, V. Monga, S. Sharma, J. Jain, A. Samad, J. Stables and A. Deep, "Synthesis, characterization and pharmacological evaluation of (E)-N′-(substituted-benzylidene) isonicotinohydrazide derivatives as potent anticonvulsant agents." Med. Chem. Res., Vol. 21, pp. 2145–2152, 2012.

[27] R. R. Somani, A. G. Agrawal, P. P. Kalantri, P. S. Gavarkar and E. D. Clercq, "Investigation of 1, 3, 4-oxadiazole scaffold as potentially active compounds." Int. J. Drug Des. Discovery, Vol. 2, pp. 353–360, 2011.