Modern Organic Chemistry Research

Download PDF (507.3 KB) PP. 1 - 9 Pub. Date: November 17, 2016

DOI: 10.22606/mocr.2016.11001

• Sudha Vengurlekar^*
  Sri Aurobindo Institute of Pharmacy, Indore, India
• Reena Gupta
  Smriti College of Pharmaceutical Education, Indore, India

N-myristoyltransferase (NMT) has been an emerging target for the design of novel antifungal agents with new mode of action. A series of furan and imidazole containing heterocyclic derivatives have been designed using rational drug designing approach as NMT inhibitors. Newly Designed compounds were synthesized, characterized and evaluated for their antifungal activity against NMT. Synthesized compounds were characterized by IR, NMR and Mass. In vitro antifungal assay indicated that these derivatives have shown moderate to good antifungal activity against five fungal strains. A possible antifungal target was identified (NMT) and furan derivatives showed more favorable affinity than the imidazole ligands.

N-myristoyltranseferase, antifungal, antibacterial, molecular modeling, minimum inhibitory concentration.

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